HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 through poison exon exclusion.
Lin, J. Q.*, Khuperkar, D.*, Pavlou, S., Makarchuk, S., Patikas, N., Lee, F. C., Kang, J. N., … & Mallucci, G. R. EMBO Journal.
Read the articlePublications
A chronological archive of research across neuronal RNA biology, local translation, imaging, and neurodegeneration.
Key publications
2020
Lin, J. Q.*, van Tartwijk, F. W.*, & Holt, C. E. Axonal mRNA translation in neurological disorders. RNA Biology.
2019
Cioni, J. M.*, Lin, J. Q.*, Holtermann, A. V., Koppers, M., Jakobs, M. A. H., Turner-Bridge, B., Azizi, A., Shigeoka, T., Franze, K., Harris, W. A., & Holt, C. E. Late endosomes act as mRNA translation platforms and sustain mitochondria in axons. Cell.
2018
Qamar, S.*, Wang, G.*, Randle, S. J.*, Ruggeri, F. S.*, Varela, J. A.*, Lin, J. Q.*, Phillips, E. C.*, Miyashita, A., Williams, D., Ströhl, F., … & St George-Hyslop, P. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-pi Interactions. Cell.
2017
Ströhl, F.*, Lin, J. Q.*, Laine, R. F., Wong, H. H., Urbančič, V., Cagnetta, R., Holt, C. E., & Kaminski, C. F. Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons. Scientific Reports.
2015
Murakami, T.*, Qamar, S.*, Lin, J. Q., Schierle, G. S. K.*, Rees, E., Miyashita, A., … & St George-Hyslop, P. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron.
Other publications
Equal contributions are marked with an asterisk in the original bibliography.
2023
Clifton, N. E., Lin, J. Q.*, Holt, C. E., O'Donovan, M. C., & Mill, J. Enrichment of the local synaptic translatome for genetic risk associated with schizophrenia and autism spectrum disorder. Biological Psychiatry.
2022
van Tartwijk, F. W., Wunderlich, L. C., Mela, I., Makarchuk, S., Jakobs, M. A., Qamar, S., … Lin, J. Q., Holt, C. E., & Kaminski, C. F. Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation. bioRxiv.
2022
Lin, J. Q., & Cioni, J. M. Live imaging of RNA transport and translation in Xenopus retinal axons. In Axonal Transport, Methods in Molecular Biology.
2020
Lu, M., van Tartwijk, F. W.*, Lin, J. Q.*, Nijenhuis, W., Parutto, P., Fantham, M., … & Kaminski, C. F. The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes. Science Advances.
2020
Ströhl, F.*, Lin, J. Q.*, van Tartwijk, F. W., Wong, H. H., Holt, C. E., & Kaminski, C. F. A Protocol for Single-Molecule Translation Imaging in Xenopus Retinal Ganglion Cells. In Single Molecule Microscopy in Neurobiology, Neuromethods.
2020
Opstad, I. S., Ströhl, F., Fantham, M., Hockings, C., Vanderpoorten, O., van Tartwijk, F. W., Lin, J. Q., … & Kaminski, C. F. A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view. Journal of Biophotonics.
2019
Koppers, M., Cagnetta, R., Shigeoka, T., Wunderlich, L. C., Vallejo-Ramirez, P., Lin, J. Q., … & Bellon, A. Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons. eLife.
2019
Shigeoka, T., Koppers, M., Wong, H. H. W.*, Lin, J. Q.*, Cagnetta, R.*, Dwivedy, A., … & Schaeffer, J. On-site ribosome remodeling by locally synthesized ribosomal proteins in axons. Cell Reports.
2018
St George-Hyslop, P., Lin, J. Q., Miyashita, A., Phillips, E. C., Qamar, S., Randle, S. J., & Wang, G. The Physiological and Pathological Biophysics of Phase Separation and Gelation of RNA Binding Proteins in Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degeneration. Brain Research.
2018
Leung, K. M.*, Lu, B.*, Wong, H. H. W.*, Lin, J. Q., Turner-Bridger, B., & Holt, C. E. Cue-polarized transport of β-actin mRNA depends on 3′ UTR and microtubules in live growth cones. Frontiers in Cellular Neuroscience.
2016
Shigeoka, T., Jung, H., Jung, J., Turner-Bridger, B., Ohk, J., Lin, J. Q., Amieux, P. S., … & Holt, C. E. Dynamic axonal translation in developing and mature visual circuits. Cell.
2016
Roque, C. G., Wong, H. H. W., Lin, J. Q., & Holt, C. E. Tumor protein Tctp regulates axon development in the embryonic visual system. Development.